Simultaneous Effect of Resistance Training and Alpha Lipoic Acid on Beclin-1 Expression and Malondialdehyde Level of Fatty Liver Diabetic Male Rats

Background: Autophagy is a genetically and evolutionarily conserved programmed process that destroys long-lived cellular proteins organelles. Objectives: The aim of this study was to evaluate the effect eight weeks strength training with alpha-lipoic acid supplementation on Becline-1 malondialdehyde concentrations in elderly diabetic rats. Methods: In experimental study, 35 old male Wistar rats were randomly divided into five groups (healthy control, diabetic, + training, supplement, supplement). At first, became had fatty liver. Then program performed weeks. Alpha-lipoic supplement also injected three days week. end period, tissues removed, expression measured by RT-PCR, concentration TBA laboratory method. For data analysis, one-way analysis variance test used for between-groups comparison (P < 0.05). Results: results showed combination (ALA) significantly reduced = 0.001) compared healthy control 0.000). Conclusions: Strength exercise combined ALA has significant role reducing rate autophagy can reduce liver type 2